Coexpressed gene networks in ATTED-II are drawn based on rank of correlation.
Use of correlation rank partially normalizes the density of genes in correlation space.
Correlation rank is asymmetric, namely the rank of gene B from gene A is not the same as the rank of gene A from gene B.
Thus, the geometric averaged rank is used.
AveRank(AB) = √ (Rank(A→B) x Rank(B→A))
For drawing coexpressed gene network of a functional category, the genes for the networks are first selected.
- Select pair of the genes that are most strongly correlated in the functional category.
- Add the pair of genes to drawing gene list.
- Stop to extract genes in following cases.
- When the AveRank between the pair of genes are larger than 50.
- When the number of non-redundant genes in drawing gene list reaches 15.
In each step of the gene extractions, the number of genes in the drawing gene list increase 0, 1 or 2. Thus in some cases, the number of genes in the drawing gene list could be 16.
- Back to the step 1.
Genes in MF:0004190 is shown in this table. They are sorted for their AveRank.
Locus1 | Locus2 | AveRank | Cor* | Drawing gene list |
At3g61820 | At1g01300 | 14.5 | 0.66 | → At3g61820, At1g01300 |
At4g22050 | At5g33340 | 19.5 | 0.54 | → At3g61820, At1g01300, At4g22050, At5g33340 |
At1g69100 | At1g31450 | 25 | 0.47 | → At3g61820, At1g01300, At4g22050, At5g33340, At1g69100, At1g31450 |
At1g31450 | At5g33340 | 33.5 | 0.46 | → At3g61820, At1g01300, At4g22050, At5g33340, At1g69100, At1g31450 |
At4g04460 | At2g03200 | 46 | 0.57 | → At3g61820, At1g01300, At4g22050, At5g33340, At1g69100, At1g31450, At4g04460, At2g03200 |
At1g25510 | At4g35880 | 109.5 | 0.58 | Stop because the AveRank is larger than 50 |
... | ... | ... | ... |
After the extraction of genes, all relationships in the drawing gene list are drawn according to the following thresholds;
AveRank | Line thickness |
1 ~ 5 | Bold lines |
5 ~ 30 | Normal lines |
30 ~ 50 | Weak lines |
50 ~ | No lines |